TY  - GEN
AU  - Stevenson,Ralph J
AU  - Denny,William A
AU  - Tercel,Moana
AU  - Pruijn,Frederik B
AU  - Ashoorzadeh,Amir
TI  - Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy
SN  - 1520-4804
PY  - 2012///0727
KW  - Animals
KW  - Antineoplastic Agents, Alkylating
KW  - chemical synthesis
KW  - Cell Hypoxia
KW  - Cell Line, Tumor
KW  - Combined Modality Therapy
KW  - Drug Screening Assays, Antitumor
KW  - Humans
KW  - Indoles
KW  - Male
KW  - Mice
KW  - Mice, Nude
KW  - Neoplasm Transplantation
KW  - Neoplasms
KW  - drug therapy
KW  - Neoplasms, Experimental
KW  - Nitro Compounds
KW  - Prodrugs
KW  - Structure-Activity Relationship
KW  - Sulfonic Acids
KW  - chemistry
KW  - Transplantation, Heterologous
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm201717y
ER  -