Stevenson, Ralph J <br/><br/>
Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.  [electronic resource] 

 -  Journal of medicinal chemistry  Mar 2012 
 - 2780-802 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm201717y  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents, Alkylating--chemical synthesis<br/>Cell Hypoxia<br/>Cell Line, Tumor<br/>Combined Modality Therapy<br/>Drug Screening Assays, Antitumor<br/>Humans<br/>Indoles--chemical synthesis<br/>Male<br/>Mice<br/>Mice, Nude<br/>Neoplasm Transplantation<br/>Neoplasms--drug therapy<br/>Neoplasms, Experimental--drug therapy<br/>Nitro Compounds--chemical synthesis<br/>Prodrugs--chemical synthesis<br/>Structure-Activity Relationship<br/>Sulfonic Acids--chemistry<br/>Transplantation, Heterologous