TY  - GEN
AU  - Borgegard,Tomas
AU  - Juréus,Anders
AU  - Olsson,Fredrik
AU  - Rosqvist,Susanne
AU  - Sabirsh,Alan
AU  - Rotticci,Didier
AU  - Paulsen,Kim
AU  - Klintenberg,Rebecka
AU  - Yan,Hongmei
AU  - Waldman,Magnus
AU  - Stromberg,Kia
AU  - Nord,Johan
AU  - Johansson,Jonas
AU  - Regner,Anna
AU  - Parpal,Santiago
AU  - Malinowsky,David
AU  - Radesater,Ann-Cathrin
AU  - Li,Tingsheng
AU  - Singh,Rajeshwar
AU  - Eriksson,Hakan
AU  - Lundkvist,Johan
TI  - First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms
SN  - 1083-351X
PY  - 2012///0606
KW  - Alanine
KW  - analogs & derivatives
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Amyloid beta-Peptides
KW  - biosynthesis
KW  - Amyloid beta-Protein Precursor
KW  - metabolism
KW  - Animals
KW  - Azepines
KW  - chemistry
KW  - Binding, Competitive
KW  - Brain
KW  - drug effects
KW  - Carbamates
KW  - pharmacology
KW  - Cell-Free System
KW  - Dibenzazepines
KW  - Dipeptides
KW  - Drug Interactions
KW  - Female
KW  - Flurbiprofen
KW  - Guinea Pigs
KW  - HEK293 Cells
KW  - Humans
KW  - Imidazoles
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Piperidines
KW  - Protein Binding
KW  - Protein Processing, Post-Translational
KW  - Pyrans
KW  - Pyridines
KW  - Pyrimidines
KW  - Rats
KW  - Receptor, EphA4
KW  - Receptor, EphB2
KW  - Receptors, Notch
KW  - Sulfonamides
KW  - Sulindac
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1074/jbc.M111.305227
ER  -