Borgegard, Tomas <br/><br/>
First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.  [electronic resource] 

 -  The Journal of biological chemistry  Apr 2012 
 - 11810-9 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M111.305227  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alanine--analogs & derivatives<br/>Amyloid Precursor Protein Secretases--antagonists & inhibitors<br/>Amyloid beta-Peptides--biosynthesis<br/>Amyloid beta-Protein Precursor--metabolism<br/>Animals<br/>Azepines--chemistry<br/>Binding, Competitive<br/>Brain--drug effects<br/>Carbamates--pharmacology<br/>Cell-Free System<br/>Dibenzazepines--pharmacology<br/>Dipeptides--pharmacology<br/>Drug Interactions<br/>Female<br/>Flurbiprofen--pharmacology<br/>Guinea Pigs<br/>HEK293 Cells<br/>Humans<br/>Imidazoles--pharmacology<br/>Mice<br/>Mice, Inbred C57BL<br/>Piperidines--pharmacology<br/>Protein Binding<br/>Protein Processing, Post-Translational--drug effects<br/>Pyrans--chemistry<br/>Pyridines--chemistry<br/>Pyrimidines--chemistry<br/>Rats<br/>Receptor, EphA4--metabolism<br/>Receptor, EphB2--metabolism<br/>Receptors, Notch--metabolism<br/>Sulfonamides--pharmacology<br/>Sulindac--analogs & derivatives