Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein. [electronic resource]
- Journal of medicinal chemistry Mar 2012
- 2144-53 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm2013503 doi
Amantadine--pharmacology Amides--chemical synthesis Animals Antiviral Agents--chemical synthesis Cell Line Dogs Drug Design Drug Resistance, Viral Influenza A Virus, H1N1 Subtype--drug effects Influenza A Virus, H3N2 Subtype--drug effects Influenza A Virus, H5N1 Subtype--drug effects Influenza A virus--drug effects Models, Molecular Nucleoproteins--metabolism Oseltamivir--pharmacology Piperazines--chemical synthesis Structure-Activity Relationship Triazoles--chemical synthesis Viral Core Proteins--metabolism Viral Plaque Assay Virus Replication--drug effects