TY  - GEN
AU  - Choo,Edna F
AU  - Belvin,Marcia
AU  - Boggs,Jason
AU  - Deng,Yuzhong
AU  - Hoeflich,Klaus P
AU  - Ly,Justin
AU  - Merchant,Mark
AU  - Orr,Christine
AU  - Plise,Emile
AU  - Robarge,Kirk
AU  - Martini,Jean F
AU  - Kassees,Robert
AU  - Aoyama,Ron G
AU  - Ramaiya,Atulkumar
AU  - Johnston,Stuart H
TI  - Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions
SN  - 1521-009X
PY  - 2012///0823
KW  - Administration, Oral
KW  - Animals
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Autoradiography
KW  - Azetidines
KW  - Bile
KW  - metabolism
KW  - Brain
KW  - Cell Line, Tumor
KW  - Cell Membrane
KW  - Cell Membrane Permeability
KW  - Colorectal Neoplasms
KW  - drug therapy
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - Female
KW  - Humans
KW  - Injections, Intravenous
KW  - Macaca fascicularis
KW  - Male
KW  - Mice
KW  - Mice, Nude
KW  - Microsomes, Liver
KW  - Models, Biological
KW  - Piperidines
KW  - Predictive Value of Tests
KW  - Prospective Studies
KW  - Protein Kinase Inhibitors
KW  - Rats
KW  - Rats, Long-Evans
KW  - Rats, Sprague-Dawley
KW  - Retrospective Studies
KW  - Species Specificity
KW  - Tissue Distribution
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.111.043778
ER  -