Choo, Edna F <br/><br/>
Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  May 2012 
 - 919-27 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.111.043778  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Autoradiography<br/>Azetidines--administration & dosage<br/>Bile--metabolism<br/>Brain--metabolism<br/>Cell Line, Tumor<br/>Cell Membrane--metabolism<br/>Cell Membrane Permeability<br/>Colorectal Neoplasms--drug therapy<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Female<br/>Humans<br/>Injections, Intravenous<br/>Macaca fascicularis<br/>Male<br/>Mice<br/>Mice, Nude<br/>Microsomes, Liver--metabolism<br/>Models, Biological<br/>Piperidines--administration & dosage<br/>Predictive Value of Tests<br/>Prospective Studies<br/>Protein Kinase Inhibitors--administration & dosage<br/>Rats<br/>Rats, Long-Evans<br/>Rats, Sprague-Dawley<br/>Retrospective Studies<br/>Species Specificity<br/>Tissue Distribution<br/>Xenograft Model Antitumor Assays