TY - GEN AU - Garcia-Marcos,Mikel AU - Kietrsunthorn,Patrick S AU - Pavlova,Yelena AU - Adia,Michelle A AU - Ghosh,Pradipta AU - Farquhar,Marilyn G TI - Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling SN - 1091-6490 PY - 2012///0330 KW - Amino Acid Motifs KW - Amino Acid Sequence KW - Cell Movement KW - drug effects KW - GTP-Binding Protein alpha Subunits, Gi-Go KW - metabolism KW - Guanine Nucleotide Exchange Factors KW - chemistry KW - HeLa Cells KW - Humans KW - Insulin KW - pharmacology KW - Lysophospholipids KW - Microfilament Proteins KW - Models, Molecular KW - Molecular Sequence Data KW - Mutant Proteins KW - Mutation KW - genetics KW - Protein Binding KW - Proto-Oncogene Proteins c-akt KW - Signal Transduction KW - Stress Fibers KW - Vesicular Transport Proteins N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1073/pnas.1120538109 ER -