Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Feb 2012
- 1961-6 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1120538109 doi
Amino Acid Motifs Amino Acid Sequence Cell Movement--drug effects GTP-Binding Protein alpha Subunits, Gi-Go--metabolism Guanine Nucleotide Exchange Factors--chemistry HeLa Cells Humans Insulin--pharmacology Lysophospholipids--pharmacology Microfilament Proteins--chemistry Models, Molecular Molecular Sequence Data Mutant Proteins--chemistry Mutation--genetics Protein Binding--drug effects Proto-Oncogene Proteins c-akt--metabolism Signal Transduction--drug effects Stress Fibers--drug effects Vesicular Transport Proteins--chemistry