TY  - GEN
AU  - Gherezghiher,Teshome B
AU  - Michalsen,Bradley
AU  - Chandrasena,R Esala P
AU  - Qin,Zhihui
AU  - Sohn,Johann
AU  - Thatcher,Gregory R J
AU  - Bolton,Judy L
TI  - The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin
SN  - 1872-7786
PY  - 2012///0523
KW  - Animals
KW  - Aryl Hydrocarbon Hydroxylases
KW  - metabolism
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - Cytochrome P-450 CYP1B1
KW  - Cytochrome P-450 CYP3A
KW  - Dose-Response Relationship, Drug
KW  - Equilenin
KW  - analogs & derivatives
KW  - Female
KW  - Half-Life
KW  - Inhibitory Concentration 50
KW  - Kinetics
KW  - Magnetic Resonance Spectroscopy
KW  - Microsomes, Liver
KW  - Naphthalenes
KW  - chemistry
KW  - Oxidation-Reduction
KW  - Piperidines
KW  - Quinones
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Selective Estrogen Receptor Modulators
KW  - Tandem Mass Spectrometry
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1016/j.cbi.2012.01.004
ER  -