Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile. [electronic resource]
- Journal of medicinal chemistry Mar 2012
- 2242-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm201506e doi
Anti-HIV Agents--chemical synthesis Cell Line, Tumor Drug Design Drug Resistance, Viral HIV Reverse Transcriptase--metabolism HIV-1--drug effects Humans Hydrogen Bonding Models, Molecular Structure-Activity Relationship Uracil--analogs & derivatives