Wang, Xiaowei

Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile. [electronic resource] - Journal of medicinal chemistry Mar 2012 - 2242-50 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm201506e doi


Anti-HIV Agents--chemical synthesis
Cell Line, Tumor
Drug Design
Drug Resistance, Viral
HIV Reverse Transcriptase--metabolism
HIV-1--drug effects
Humans
Hydrogen Bonding
Models, Molecular
Structure-Activity Relationship
Uracil--analogs & derivatives