TY - GEN AU - Jaumann,Mirko AU - Dettling,Juliane AU - Gubelt,Martin AU - Zimmermann,Ulrike AU - Gerling,Andrea AU - Paquet-Durand,François AU - Feil,Susanne AU - Wolpert,Stephan AU - Franz,Christoph AU - Varakina,Ksenya AU - Xiong,Hao AU - Brandt,Niels AU - Kuhn,Stephanie AU - Geisler,Hyun-Soon AU - Rohbock,Karin AU - Ruth,Peter AU - Schlossmann,Jens AU - Hütter,Joachim AU - Sandner,Peter AU - Feil,Robert AU - Engel,Jutta AU - Knipper,Marlies AU - Rüttiger,Lukas TI - cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function SN - 1546-170X PY - 2012///0329 KW - Animals KW - Cyclic GMP-Dependent Protein Kinase Type I KW - Cyclic GMP-Dependent Protein Kinases KW - physiology KW - Cyclic Nucleotide Phosphodiesterases, Type 5 KW - drug effects KW - Enzyme Activation KW - Female KW - Hair Cells, Auditory KW - metabolism KW - Hair Cells, Auditory, Inner KW - Hair Cells, Auditory, Outer KW - Hearing Loss, Noise-Induced KW - genetics KW - Imidazoles KW - pharmacology KW - Mice KW - Mice, Mutant Strains KW - Noise KW - adverse effects KW - Phosphodiesterase 5 Inhibitors KW - Piperazines KW - Poly Adenosine Diphosphate Ribose KW - biosynthesis KW - Poly(ADP-ribose) Polymerases KW - Rats KW - Rats, Wistar KW - Signal Transduction KW - Sulfones KW - Triazines KW - Up-Regulation KW - Vardenafil Dihydrochloride N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nm.2634 ER -