Reddiconto, Giovanni <br/><br/>
Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells.  [electronic resource] 

 -  Blood  Mar 2012 
 - 2335-45 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1528-0020 
<br/><br/><label>Standard No.: </label>10.1182/blood-2011-06-361261  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antigens, CD34--metabolism<br/>Apoptosis--drug effects<br/>Benzamides<br/>Blotting, Western<br/>Cell Nucleus--metabolism<br/>Cells, Cultured<br/>Cyclin D1--metabolism<br/>Cytokines--pharmacology<br/>Dasatinib<br/>Drug Synergism<br/>Fusion Proteins, bcr-abl--antagonists & inhibitors<br/>Glycogen Synthase Kinase 3--antagonists & inhibitors<br/>Glycogen Synthase Kinase 3 beta<br/>Hematopoietic Stem Cells--drug effects<br/>Humans<br/>Imatinib Mesylate<br/>Indoles--pharmacology<br/>Leukemia, Myelogenous, Chronic, BCR-ABL Positive--genetics<br/>Maleimides--pharmacology<br/>Microscopy, Confocal<br/>Mitogen-Activated Protein Kinases--metabolism<br/>Neoplastic Stem Cells--drug effects<br/>Phosphorylation--drug effects<br/>Piperazines--pharmacology<br/>Protein Kinase Inhibitors--pharmacology<br/>Protein Transport--drug effects<br/>Proto-Oncogene Proteins pp60(c-src)--metabolism<br/>Pyrimidines--pharmacology<br/>Signal Transduction--drug effects<br/>Thiazoles--pharmacology<br/>beta Catenin--metabolism