Siegfried, Jill M

Combining the multitargeted tyrosine kinase inhibitor vandetanib with the antiestrogen fulvestrant enhances its antitumor effect in non-small cell lung cancer. [electronic resource] - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Mar 2012 - 485-95 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1556-1380

10.1097/JTO.0b013e31824177ea doi


Animals
Antineoplastic Combined Chemotherapy Protocols
Apoptosis--drug effects
Blotting, Western
Carcinoma, Non-Small-Cell Lung--drug therapy
Cell Proliferation--drug effects
Drug Synergism
Enzyme-Linked Immunosorbent Assay
ErbB Receptors--antagonists & inhibitors
Estradiol--analogs & derivatives
Estrogen Receptor Modulators--pharmacology
Estrogens--pharmacology
Female
Fluorescent Antibody Technique
Fulvestrant
Humans
Immunoenzyme Techniques
Lung Neoplasms--drug therapy
Mice
Mice, SCID
Piperidines--pharmacology
Protein Kinase Inhibitors--pharmacology
Protein-Tyrosine Kinases--antagonists & inhibitors
Quinazolines--pharmacology
RNA, Messenger--genetics
Real-Time Polymerase Chain Reaction
Tumor Cells, Cultured
Vascular Endothelial Growth Factor A--antagonists & inhibitors
Vascular Endothelial Growth Factor Receptor-3--antagonists & inhibitors