Chu, Seung Y

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody. [electronic resource] - The Journal of allergy and clinical immunology Apr 2012 - 1102-15 p. digital

Publication Type: Journal Article

1097-6825

10.1016/j.jaci.2011.11.029 doi


Animals
Anti-Allergic Agents--pharmacology
Antibodies, Anti-Idiotypic--blood
Antibodies, Monoclonal, Humanized--blood
Antibody Affinity--immunology
B-Lymphocytes--drug effects
Humans
Immunoglobulin E--biosynthesis
Immunoglobulin Fc Fragments--genetics
Immunoglobulin G--biosynthesis
Immunoglobulin M--biosynthesis
Leukocytes, Mononuclear--metabolism
Lymphocyte Activation--immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, SCID
Omalizumab
Protein Binding--immunology
Receptors, Antigen, B-Cell--antagonists & inhibitors
Receptors, IgE--antagonists & inhibitors
Receptors, IgG--antagonists & inhibitors