Chu, Seung Y
Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody. [electronic resource]
- The Journal of allergy and clinical immunology Apr 2012
- 1102-15 p. digital
Publication Type: Journal Article
ISSN: 1097-6825
Standard No.: 10.1016/j.jaci.2011.11.029 doi
Subjects--Topical Terms: Animals Anti-Allergic Agents--pharmacology Antibodies, Anti-Idiotypic--blood Antibodies, Monoclonal, Humanized--blood Antibody Affinity--immunology B-Lymphocytes--drug effects Humans Immunoglobulin E--biosynthesis Immunoglobulin Fc Fragments--genetics Immunoglobulin G--biosynthesis Immunoglobulin M--biosynthesis Leukocytes, Mononuclear--metabolism Lymphocyte Activation--immunology Mice Mice, Inbred C57BL Mice, Knockout Mice, SCID Omalizumab Protein Binding--immunology Receptors, Antigen, B-Cell--antagonists & inhibitors Receptors, IgE--antagonists & inhibitors Receptors, IgG--antagonists & inhibitors