Astanehe, A <br/><br/>
MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition.  [electronic resource] 

 -  Oncogene  Oct 2012 
 - 4434-46 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-5594 
<br/><br/><label>Standard No.: </label>10.1038/onc.2011.617  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antibodies, Monoclonal, Humanized--pharmacology<br/>Antineoplastic Agents--pharmacology<br/>Apoptosis<br/>Base Sequence<br/>Breast Neoplasms--drug therapy<br/>Cell Line, Tumor<br/>Chromatin Immunoprecipitation<br/>Drug Resistance, Neoplasm--genetics<br/>Female<br/>Gene Expression Regulation, Neoplastic<br/>Gene Knockdown Techniques<br/>Humans<br/>Intracellular Signaling Peptides and Proteins--genetics<br/>Phosphorylation<br/>Protein Array Analysis<br/>Protein Processing, Post-Translational<br/>Protein Serine-Threonine Kinases--genetics<br/>Pteridines--pharmacology<br/>Ribosomal Protein S6 Kinases, 90-kDa--antagonists & inhibitors<br/>Sequence Analysis, DNA<br/>Transcription, Genetic<br/>Trastuzumab<br/>Y-Box-Binding Protein 1--metabolism