Airiau, Kelly <br/><br/>
ABT-737 increases tyrosine kinase inhibitor-induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34(+) CD38(-) population to imatinib.  [electronic resource] 

 -  Experimental hematology  May 2012 
 - 367-78.e2 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1873-2399 
<br/><br/><label>Standard No.: </label>10.1016/j.exphem.2012.01.004  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antigens, CD34--analysis<br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Apoptosis Regulatory Proteins--physiology<br/>Bcl-2-Like Protein 11<br/>Benzamides<br/>Biphenyl Compounds--pharmacology<br/>Cell Line, Tumor--drug effects<br/>Down-Regulation--drug effects<br/>Drug Resistance, Neoplasm--drug effects<br/>Drug Screening Assays, Antitumor<br/>Drug Synergism<br/>Gene Expression Regulation, Leukemic--drug effects<br/>Hematopoietic Stem Cells--drug effects<br/>High-Temperature Requirement A Serine Peptidase 2<br/>Humans<br/>Imatinib Mesylate<br/>K562 Cells--drug effects<br/>Leukemia, Myelogenous, Chronic, BCR-ABL Positive--pathology<br/>Membrane Proteins--physiology<br/>Mitochondrial Proteins--physiology<br/>Neoplasm Proteins--biosynthesis<br/>Neoplastic Stem Cells--drug effects<br/>Nitrophenols--pharmacology<br/>Piperazines--pharmacology<br/>Protein Kinase Inhibitors--pharmacology<br/>Proto-Oncogene Proteins--physiology<br/>Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors<br/>Pyrimidines--pharmacology<br/>Serine Endopeptidases--physiology<br/>Sulfonamides--pharmacology<br/>X-Linked Inhibitor of Apoptosis Protein--biosynthesis