TY - GEN AU - Léon,Catherine AU - Evert,Katja AU - Dombrowski,Frank AU - Pertuy,Fabien AU - Eckly,Anita AU - Laeuffer,Patricia AU - Gachet,Christian AU - Greinacher,Andreas TI - Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD SN - 1528-0020 PY - 2012///0619 KW - Animals KW - Bleeding Time KW - Blood Platelets KW - drug effects KW - Bone Marrow KW - metabolism KW - Embolism KW - chemically induced KW - Factor IX KW - Factor V KW - Female KW - Leukocyte Count KW - Lung KW - pathology KW - Male KW - Megakaryocytes KW - Membrane Glycoproteins KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Myosin Heavy Chains KW - Nonmuscle Myosin Type IIA KW - genetics KW - P-Selectin KW - Platelet Count KW - Platelet Glycoprotein GPIIb-IIIa Complex KW - Platelet Membrane Glycoproteins KW - Primary Myelofibrosis KW - Receptors, Fc KW - administration & dosage KW - Recombinant Fusion Proteins KW - Reticulin KW - Spleen KW - cytology KW - Thrombocytopenia KW - Thrombopoietin N1 - Publication Type: Journal Article UR - https://doi.org/10.1182/blood-2011-08-373811 ER -