Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein. [electronic resource]
- British journal of pharmacology Jul 2012
- 1669-83 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5381
10.1111/j.1476-5381.2012.01849.x doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors Adenosine Triphosphatases--metabolism Animals Antineoplastic Agents--pharmacology Cell Line, Tumor Crizotinib Doxorubicin--pharmacokinetics Drug Resistance, Multiple--drug effects Drug Resistance, Neoplasm--drug effects Female Humans Mice Mice, Nude Neoplasms--drug therapy Paclitaxel--therapeutic use Protein Kinase Inhibitors--pharmacology Pyrazoles--pharmacology Pyridines--pharmacology Rhodamine 123--pharmacokinetics Tumor Burden--drug effects Xenograft Model Antitumor Assays