Wnt3a stimulates Mepe, matrix extracellular phosphoglycoprotein, expression directly by the activation of the canonical Wnt signaling pathway and indirectly through the stimulation of autocrine Bmp-2 expression. [electronic resource]
- Journal of cellular physiology Jun 2012
- 2287-96 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1097-4652
10.1002/jcp.24038 doi
3T3 Cells Animals Autocrine Communication Base Sequence Binding Sites Bone Morphogenetic Protein 2--genetics Calcification, Physiologic Carrier Proteins--metabolism Culture Media, Conditioned--metabolism Extracellular Matrix Proteins--genetics Genes, Reporter Glycoproteins--genetics Homeodomain Proteins--genetics Intercellular Signaling Peptides and Proteins--metabolism Lymphoid Enhancer-Binding Factor 1--metabolism Mice Molecular Sequence Data Myoblasts--metabolism Osteogenesis Phosphoproteins--genetics Phosphorylation Promoter Regions, Genetic RNA Interference RNA, Messenger--metabolism Recombinant Proteins--metabolism Smad1 Protein--metabolism Smad5 Protein--metabolism Time Factors Transfection Up-Regulation Wnt Signaling Pathway Wnt3A Protein--metabolism beta Catenin--metabolism