Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. [electronic resource]
- Molecular cancer therapeutics Feb 2012
- 427-38 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1538-8514
10.1158/1535-7163.MCT-11-0406 doi
Antimetabolites--pharmacology Antineoplastic Agents--pharmacology Blotting, Western Camptothecin--analogs & derivatives Cell Cycle Checkpoints--drug effects Cell Line Cell Line, Tumor Cell Proliferation--drug effects Cell Survival--drug effects Checkpoint Kinase 1 Cytarabine--pharmacology DNA Breaks, Double-Stranded--drug effects DNA Damage Deoxycytidine--analogs & derivatives Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Drug Synergism Flow Cytometry Humans Hydroxyurea--pharmacology Irinotecan Molecular Structure Phosphorylation--drug effects Protein Kinase Inhibitors--chemistry Protein Kinases--metabolism Pyrazoles--chemistry Pyrimidines--chemistry Staurosporine--analogs & derivatives Gemcitabine