Montaseri, Azadeh <br/><br/>
IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.  [electronic resource] 

 -  PloS one  2011 
 - e28663 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1932-6203 
<br/><br/><label>Standard No.: </label>10.1371/journal.pone.0028663  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis--drug effects<br/>Becaplermin<br/>Cartilage--drug effects<br/>Cell Differentiation--drug effects<br/>Cells, Cultured<br/>Chondrocytes--drug effects<br/>Collagen Type II--metabolism<br/>Dogs<br/>Down-Regulation--drug effects<br/>Enzyme Activation--drug effects<br/>Extracellular Matrix--drug effects<br/>Extracellular Signal-Regulated MAP Kinases--metabolism<br/>I-kappa B Proteins--metabolism<br/>Imidazoles--pharmacology<br/>Insulin-Like Growth Factor I--pharmacology<br/>Integrin beta1--metabolism<br/>Interleukin-1beta--pharmacology<br/>NF-KappaB Inhibitor alpha<br/>NF-kappa B--metabolism<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphorylation--drug effects<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Proto-Oncogene Proteins c-sis--pharmacology<br/>Quinoxalines--pharmacology<br/>SOX9 Transcription Factor--metabolism<br/>Shc Signaling Adaptor Proteins--metabolism<br/>Signal Transduction--drug effects<br/>src-Family Kinases--metabolism