Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain. [electronic resource]
- Journal of Alzheimer's disease : JAD 2012
- 951-60 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1875-8908
10.3233/JAD-2011-111517 doi
Aging--metabolism Amyloid beta-Protein Precursor--antagonists & inhibitors Animals Brain--drug effects Drug Delivery Systems Gene Expression Regulation Low Density Lipoprotein Receptor-Related Protein-1 Male Mice Mice, Transgenic Oligonucleotides, Antisense--administration & dosage Receptors, LDL--antagonists & inhibitors Tumor Suppressor Proteins--antagonists & inhibitors