TY  - GEN
AU  - Sanchez,Carlos J
AU  - Kumar,Nikhil
AU  - Lizcano,Anel
AU  - Shivshankar,Pooja
AU  - Dunning Hotopp,Julie C
AU  - Jorgensen,James H
AU  - Tettelin,Hervé
AU  - Orihuela,Carlos J
TI  - Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production
SN  - 1932-6203
PY  - 2012///0423
KW  - Animals
KW  - Anti-Infective Agents
KW  - pharmacology
KW  - Bacterial Adhesion
KW  - drug effects
KW  - Bacterial Capsules
KW  - biosynthesis
KW  - Bacterial Proteins
KW  - Biofilms
KW  - Cell Line
KW  - Gene Expression Regulation, Bacterial
KW  - Humans
KW  - Mice
KW  - Microbial Sensitivity Tests
KW  - Phenotype
KW  - Plankton
KW  - Pneumococcal Infections
KW  - microbiology
KW  - Reproducibility of Results
KW  - Streptococcus pneumoniae
KW  - Streptolysins
KW  - Time Factors
KW  - Virulence
KW  - Virulence Factors
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0028738
ER  -