WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. [electronic resource]
- Journal of cell science Dec 2011
- 3967-79 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
1477-9137
10.1242/jcs.081372 doi
Ataxia Telangiectasia Mutated Proteins Camptothecin--pharmacology Cell Cycle Proteins--genetics Cell Line, Tumor Checkpoint Kinase 1 Chromatin--genetics Chromatin Immunoprecipitation DNA Damage DNA Replication DNA, Single-Stranded--genetics Exodeoxyribonucleases--genetics Gene Expression Regulation, Enzymologic Gene Knockdown Techniques Genomic Instability Humans Hydroxyurea--pharmacology Phosphorylation Protein Kinases--genetics Protein Serine-Threonine Kinases--genetics RNA, Small Interfering--genetics RecQ Helicases--genetics S Phase Cell Cycle Checkpoints Topoisomerase I Inhibitors--pharmacology Werner Syndrome Helicase