TY  - GEN
AU  - Shah,Dhaval K
AU  - Betts,Alison M
TI  - Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
SN  - 1573-8744
PY  - 2012///0927
KW  - Adalimumab
KW  - Algorithms
KW  - Animal Structures
KW  - metabolism
KW  - Animals
KW  - Antibodies, Monoclonal
KW  - blood
KW  - Antibodies, Monoclonal, Humanized
KW  - Antigens, Neoplasm
KW  - immunology
KW  - Area Under Curve
KW  - Blood
KW  - Drug Evaluation, Preclinical
KW  - methods
KW  - Endosomes
KW  - Extracellular Space
KW  - Haplorhini
KW  - Histocompatibility Antigens Class I
KW  - genetics
KW  - Humans
KW  - Immunoglobulins, Intravenous
KW  - administration & dosage
KW  - Lymph
KW  - Male
KW  - Mice
KW  - Mice, Knockout
KW  - Models, Biological
KW  - Neoplasms
KW  - Pinocytosis
KW  - physiology
KW  - Rats
KW  - Receptors, Fc
KW  - Tissue Distribution
KW  - drug effects
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1007/s10928-011-9232-2
ER  -