Shah, Dhaval K <br/><br/>
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.  [electronic resource] 

 -  Journal of pharmacokinetics and pharmacodynamics  Feb 2012 
 - 67-86 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1573-8744 
<br/><br/><label>Standard No.: </label>10.1007/s10928-011-9232-2  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adalimumab<br/>Algorithms<br/>Animal Structures--metabolism<br/>Animals<br/>Antibodies, Monoclonal--blood<br/>Antibodies, Monoclonal, Humanized--blood<br/>Antigens, Neoplasm--immunology<br/>Area Under Curve<br/>Blood--metabolism<br/>Drug Evaluation, Preclinical--methods<br/>Endosomes--metabolism<br/>Extracellular Space--metabolism<br/>Haplorhini<br/>Histocompatibility Antigens Class I--genetics<br/>Humans<br/>Immunoglobulins, Intravenous--administration & dosage<br/>Lymph--metabolism<br/>Male<br/>Mice<br/>Mice, Knockout<br/>Models, Biological<br/>Neoplasms--immunology<br/>Pinocytosis--physiology<br/>Rats<br/>Receptors, Fc--genetics<br/>Tissue Distribution--drug effects<br/>Xenograft Model Antitumor Assays