TY  - GEN
AU  - van Westen,Gerard J P
AU  - Wegner,Jörg K
AU  - Geluykens,Peggy
AU  - Kwanten,Leen
AU  - Vereycken,Inge
AU  - Peeters,Anik
AU  - Ijzerman,Adriaan P
AU  - van Vlijmen,Herman W T
AU  - Bender,Andreas
TI  - Which compound to select in lead optimization? Prospectively validated proteochemometric models guide preclinical development
SN  - 1932-6203
PY  - 2012///0402
KW  - Amino Acid Sequence
KW  - Binding Sites
KW  - Databases as Topic
KW  - Drug Evaluation, Preclinical
KW  - methods
KW  - HIV Reverse Transcriptase
KW  - antagonists & inhibitors
KW  - Humans
KW  - Ligands
KW  - Models, Molecular
KW  - Molecular Sequence Data
KW  - Mutation
KW  - genetics
KW  - Proteomics
KW  - Reproducibility of Results
KW  - Reverse Transcriptase Inhibitors
KW  - analysis
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0027518
ER  -