TY - GEN AU - Wise,David R AU - Ward,Patrick S AU - Shay,Jessica E S AU - Cross,Justin R AU - Gruber,Joshua J AU - Sachdeva,Uma M AU - Platt,Jesse M AU - DeMatteo,Raymond G AU - Simon,M Celeste AU - Thompson,Craig B TI - Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability SN - 1091-6490 PY - 2012///0413 KW - Carboxylic Acids KW - metabolism KW - Cell Hypoxia KW - Cell Line, Tumor KW - Cell Proliferation KW - Cell Survival KW - Citrates KW - Citric Acid Cycle KW - Gas Chromatography-Mass Spectrometry KW - Glucose KW - Glutamine KW - Humans KW - Hypoxia-Inducible Factor 1 KW - genetics KW - Immunoblotting KW - Isocitrate Dehydrogenase KW - Ketoglutaric Acids KW - Neoplasms KW - Oxidation-Reduction KW - RNA Interference N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1073/pnas.1117773108 ER -