TY  - GEN
AU  - May,Patrick C
AU  - Dean,Robert A
AU  - Lowe,Stephen L
AU  - Martenyi,Ferenc
AU  - Sheehan,Scott M
AU  - Boggs,Leonard N
AU  - Monk,Scott A
AU  - Mathes,Brian M
AU  - Mergott,Dustin J
AU  - Watson,Brian M
AU  - Stout,Stephanie L
AU  - Timm,David E
AU  - Smith Labell,Elizabeth
AU  - Gonzales,Celedon R
AU  - Nakano,Masako
AU  - Jhee,Stanford S
AU  - Yen,Mark
AU  - Ereshefsky,Larry
AU  - Lindstrom,Terry D
AU  - Calligaro,David O
AU  - Cocke,Patrick J
AU  - Greg Hall,D
AU  - Friedrich,Stuart
AU  - Citron,Martin
AU  - Audia,James E
TI  - Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor
SN  - 1529-2401
PY  - 2012///0112
KW  - Adult
KW  - Alzheimer Disease
KW  - cerebrospinal fluid
KW  - Amyloid Precursor Protein Secretases
KW  - analysis
KW  - Amyloid beta-Peptides
KW  - Amyloid beta-Protein Precursor
KW  - Analysis of Variance
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Cells, Cultured
KW  - Cerebral Cortex
KW  - cytology
KW  - Crystallography
KW  - methods
KW  - Disease Models, Animal
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - Embryo, Mammalian
KW  - Enzyme Inhibitors
KW  - blood
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Female
KW  - Humans
KW  - Male
KW  - Mice
KW  - Mice, Transgenic
KW  - Middle Aged
KW  - Models, Chemical
KW  - Mutation
KW  - genetics
KW  - Neurons
KW  - drug effects
KW  - Peptide Fragments
KW  - Pyrimidines
KW  - pharmacology
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Thiazines
KW  - Time Factors
KW  - Young Adult
N1  - Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1523/JNEUROSCI.3647-11.2011
ER  -