May, Patrick C <br/><br/>
Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.  [electronic resource] 

 -  The Journal of neuroscience : the official journal of the Society for Neuroscience  Nov 2011 
 - 16507-16 p.  digital 
<br/><br/> Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1529-2401 
<br/><br/><label>Standard No.: </label>10.1523/JNEUROSCI.3647-11.2011  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Alzheimer Disease--cerebrospinal fluid<br/>Amyloid Precursor Protein Secretases--analysis<br/>Amyloid beta-Peptides--cerebrospinal fluid<br/>Amyloid beta-Protein Precursor--cerebrospinal fluid<br/>Analysis of Variance<br/>Animals<br/>Aspartic Acid Endopeptidases--analysis<br/>Cells, Cultured<br/>Cerebral Cortex--cytology<br/>Crystallography--methods<br/>Disease Models, Animal<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Embryo, Mammalian<br/>Enzyme Inhibitors--blood<br/>Enzyme-Linked Immunosorbent Assay--methods<br/>Female<br/>Humans<br/>Male<br/>Mice<br/>Mice, Transgenic<br/>Middle Aged<br/>Models, Chemical<br/>Mutation--genetics<br/>Neurons--drug effects<br/>Peptide Fragments--cerebrospinal fluid<br/>Pyrimidines--pharmacology<br/>Rats<br/>Rats, Sprague-Dawley<br/>Thiazines--pharmacology<br/>Time Factors<br/>Young Adult