TY - GEN AU - Ikejima,M AU - Noguchi,S AU - Yamashita,R AU - Ogura,T AU - Sugimura,T AU - Gill,D M AU - Miwa,M TI - The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA SN - 0021-9258 PY - 1991///0123 KW - Amino Acid Sequence KW - Base Sequence KW - Cloning, Molecular KW - Cysteine KW - physiology KW - DNA KW - metabolism KW - DNA Damage KW - DNA Mutational Analysis KW - DNA Repair KW - DNA-Binding Proteins KW - genetics KW - Enzyme Activation KW - Humans KW - Molecular Sequence Data KW - Poly(ADP-ribose) Polymerases KW - Structure-Activity Relationship KW - Substrate Specificity KW - Zinc Fingers N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S ER -