The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA. [electronic resource]
- The Journal of biological chemistry Dec 1990
- 21907-13 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
0021-9258
Amino Acid Sequence Base Sequence Cloning, Molecular Cysteine--physiology DNA--metabolism DNA Damage DNA Mutational Analysis DNA Repair DNA-Binding Proteins--genetics Enzyme Activation Humans Molecular Sequence Data Poly(ADP-ribose) Polymerases--genetics Structure-Activity Relationship Substrate Specificity Zinc Fingers