TY - GEN AU - Powell,Rebecca D AU - Holland,Paul J AU - Hollis,Thomas AU - Perrino,Fred W TI - Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase SN - 1083-351X PY - 2012///0221 KW - Animals KW - Autoimmune Diseases KW - genetics KW - Autoimmune Diseases of the Nervous System KW - Catalysis KW - Cattle KW - Deoxyguanine Nucleotides KW - chemistry KW - Dose-Response Relationship, Drug KW - HIV-1 KW - Humans KW - Mice KW - Monomeric GTP-Binding Proteins KW - Myeloid Cells KW - cytology KW - Nervous System Malformations KW - Nucleosides KW - Phosphoric Monoester Hydrolases KW - SAM Domain and HD Domain-Containing Protein 1 KW - Viral Regulatory and Accessory Proteins KW - metabolism KW - Virus Replication N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1074/jbc.C111.317628 ER -