Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism. [electronic resource]
- Neuroscience Jan 2012
- 199-210 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1873-7544
10.1016/j.neuroscience.2011.10.019 doi
Analysis of Variance Animals Anti-Inflammatory Agents, Non-Steroidal--therapeutic use Calcium-Binding Proteins Cells, Cultured DNA-Binding Proteins--metabolism Dipeptides--therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Enzyme Inhibitors--therapeutic use Enzyme-Linked Immunosorbent Assay--methods Etanercept Gene Expression Regulation--drug effects Glial Fibrillary Acidic Protein--metabolism Hydroxamic Acids--therapeutic use Hyperalgesia--drug therapy Immunoglobulin G--therapeutic use Inflammation--chemically induced Lipopolysaccharides Male Matrix Metalloproteinase 3--administration & dosage Microfilament Proteins Neuroglia--drug effects Pain Measurement Pain Threshold--drug effects Physical Stimulation Rats Rats, Sprague-Dawley Reaction Time--drug effects Receptors, Tumor Necrosis Factor--therapeutic use Spinal Cord--drug effects Sulfonamides--therapeutic use Time Factors Tumor Necrosis Factors--metabolism