Ln, Ramya <br/><br/>
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia.  [electronic resource] 

 -  Journal of pediatric hematology/oncology  Dec 2011 
 - 617-21 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1536-3678 
<br/><br/><label>Standard No.: </label>10.1097/MPH.0b013e31822aa4ec  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Asparaginase--chemistry<br/>Asparagine--chemistry<br/>Catalytic Domain<br/>Child<br/>Computer Simulation<br/>Drug Design<br/>Glutaminase--chemistry<br/>Glutamine--chemistry<br/>Humans<br/>Ligands<br/>Mutagenesis, Site-Directed<br/>Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy<br/>Protein Engineering--methods