Chenna, Venugopal <br/><br/>
A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.  [electronic resource] 

 -  Molecular cancer therapeutics  Jan 2012 
 - 165-73 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1538-8514 
<br/><br/><label>Standard No.: </label>10.1158/1535-7163.MCT-11-0341  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Cell Line, Tumor<br/>Cell Proliferation<br/>Deoxycytidine--analogs & derivatives<br/>Hedgehog Proteins--antagonists & inhibitors<br/>Humans<br/>Male<br/>Medulloblastoma--metabolism<br/>Mice<br/>Mice, Nude<br/>Nanoparticles--chemistry<br/>Pancreatic Neoplasms--metabolism<br/>Patched Receptors<br/>Patched-1 Receptor<br/>Receptors, Cell Surface--genetics<br/>Receptors, G-Protein-Coupled--antagonists & inhibitors<br/>Signal Transduction<br/>Smoothened Receptor<br/>Transcription Factors--antagonists & inhibitors<br/>Tumor Suppressor Protein p53--genetics<br/>Xenograft Model Antitumor Assays<br/>Zinc Finger Protein GLI1<br/>Gemcitabine