TY - GEN AU - Kim,Jae-Ick AU - Lee,Hye-Ryeon AU - Sim,Su-eon AU - Baek,Jinhee AU - Yu,Nam-Kyung AU - Choi,Jun-Hyeok AU - Ko,Hyoung-Gon AU - Lee,Yong-Seok AU - Park,Soo-Won AU - Kwak,Chuljung AU - Ahn,Sung-Ji AU - Choi,So Yoen AU - Kim,Hyun AU - Kim,Kyoung-Han AU - Backx,Peter H AU - Bradley,Clarrisa A AU - Kim,Eunjoon AU - Jang,Deok-Jin AU - Lee,Kyungmin AU - Kim,Sang Jeong AU - Zhuo,Min AU - Collingridge,Graham L AU - Kaang,Bong-Kiun TI - PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility SN - 1546-1726 PY - 2011///1221 KW - Analysis of Variance KW - Animals KW - Behavior, Animal KW - drug effects KW - Biophysics KW - Chromones KW - pharmacology KW - Class Ib Phosphatidylinositol 3-Kinase KW - deficiency KW - Conditioning, Classical KW - Electric Stimulation KW - methods KW - Environment KW - Enzyme Inhibitors KW - Excitatory Amino Acid Agents KW - Excitatory Postsynaptic Potentials KW - Exploratory Behavior KW - Extinction, Psychological KW - physiology KW - Fear KW - Female KW - Gene Expression Regulation KW - Glycogen Synthase Kinase 3 KW - metabolism KW - Glycogen Synthase Kinase 3 beta KW - Hippocampus KW - cytology KW - In Vitro Techniques KW - Long-Term Synaptic Depression KW - Male KW - Maze Learning KW - Methoxyhydroxyphenylglycol KW - analogs & derivatives KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Morpholines KW - Neurons KW - Oncogene Protein v-akt KW - genetics KW - Phosphorylation KW - Quinoxalines KW - RNA, Messenger KW - Receptors, N-Methyl-D-Aspartate KW - Signal Transduction KW - Thiazolidinediones KW - Time Factors N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nn.2937 ER -