TY  - GEN
AU  - Manfredi,Mark G
AU  - Ecsedy,Jeffrey A
AU  - Chakravarty,Arijit
AU  - Silverman,Lee
AU  - Zhang,Mengkun
AU  - Hoar,Kara M
AU  - Stroud,Stephen G
AU  - Chen,Wei
AU  - Shinde,Vaishali
AU  - Huck,Jessica J
AU  - Wysong,Deborah R
AU  - Janowick,David A
AU  - Hyer,Marc L
AU  - Leroy,Patrick J
AU  - Gershman,Rachel E
AU  - Silva,Matthew D
AU  - Germanos,Melissa S
AU  - Bolen,Joseph B
AU  - Claiborne,Christopher F
AU  - Sells,Todd B
TI  - Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays
SN  - 1557-3265
PY  - 2012///0611
KW  - Animals
KW  - Aurora Kinase A
KW  - Aurora Kinases
KW  - Azepines
KW  - chemistry
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Dideoxynucleosides
KW  - pharmacokinetics
KW  - Female
KW  - Fluorine Radioisotopes
KW  - HCT116 Cells
KW  - HeLa Cells
KW  - Humans
KW  - Lymphoma
KW  - drug therapy
KW  - Mice
KW  - Mice, Nude
KW  - Mice, SCID
KW  - Mitotic Index
KW  - Molecular Structure
KW  - Neoplasms
KW  - Phosphorylation
KW  - Positron-Emission Tomography
KW  - Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Pyrimidines
KW  - Spindle Apparatus
KW  - Tumor Burden
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1078-0432.CCR-11-1536
ER  -