Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. [electronic resource]
- Circulation research Nov 2011
- 1269-79 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1524-4571
10.1161/CIRCRESAHA.111.247684 doi
Amino Acid Motifs Animals Atherosclerosis--genetics Bleeding Time Blood Coagulation--drug effects CD40 Ligand--metabolism CHO Cells Cells, Cultured Chemotaxis, Leukocyte--physiology Cricetinae Humans Macrophage-1 Antigen--metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Models, Molecular Peptide Fragments--pharmacology Peptides, Cyclic--pharmacology Peritonitis--blood Protein Conformation Protein Interaction Mapping Protein Structure, Tertiary Receptors, LDL--deficiency Recombinant Fusion Proteins--physiology Surface Plasmon Resonance Thrombosis--etiology