Jing, Yi

Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells. [electronic resource] - Toxicological sciences : an official journal of the Society of Toxicology Jan 2012 - 10-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1096-0929

10.1093/toxsci/kfr256 doi


Animals
Blotting, Western
Bronchi--blood supply
Cadmium--toxicity
Cell Culture Techniques
Cell Line
Cell Transformation, Neoplastic--chemically induced
Chick Embryo
Chorioallantoic Membrane--blood supply
Dose-Response Relationship, Drug
Epithelial Cells--drug effects
Female
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--biosynthesis
MAP Kinase Signaling System--drug effects
Mice
Microscopy, Fluorescence
Neoplasm Transplantation
Neovascularization, Pathologic--chemically induced
Proto-Oncogene Proteins c-akt--metabolism
Reactive Oxygen Species--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
Vascular Endothelial Growth Factor A--biosynthesis