Chang, Kwang-Yu

Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Nov 2011 - 7116-26 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1557-3265

10.1158/1078-0432.CCR-11-0796 doi


Animals
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Evaluation, Preclinical
Head and Neck Neoplasms--drug therapy
Humans
Imidazoles--therapeutic use
Male
Mice
Mice, Nude
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors--pharmacology
Quinolines--therapeutic use
Signal Transduction--drug effects
TOR Serine-Threonine Kinases--antagonists & inhibitors
Xenograft Model Antitumor Assays