Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. [electronic resource]
- Clinical cancer research : an official journal of the American Association for Cancer Research Nov 2011
- 7116-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1557-3265
10.1158/1078-0432.CCR-11-0796 doi
Animals Antineoplastic Agents Cell Line, Tumor Cell Proliferation--drug effects Drug Evaluation, Preclinical Head and Neck Neoplasms--drug therapy Humans Imidazoles--therapeutic use Male Mice Mice, Nude Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors--pharmacology Quinolines--therapeutic use Signal Transduction--drug effects TOR Serine-Threonine Kinases--antagonists & inhibitors Xenograft Model Antitumor Assays