TY  - GEN
AU  - Lowes,David J
AU  - Guiguemde,W Armand
AU  - Connelly,Michele C
AU  - Zhu,Fangyi
AU  - Sigal,Martina S
AU  - Clark,Julie A
AU  - Lemoff,Andrew S
AU  - Derisi,Joseph L
AU  - Wilson,Emily B
AU  - Guy,R Kiplin
TI  - Optimization of propafenone analogues as antimalarial leads
SN  - 1520-4804
PY  - 2012///0207
KW  - Animals
KW  - Antimalarials
KW  - chemical synthesis
KW  - Cell Line
KW  - Drug Resistance
KW  - Female
KW  - Humans
KW  - In Vitro Techniques
KW  - Ion Channels
KW  - antagonists & inhibitors
KW  - Male
KW  - Membranes, Artificial
KW  - Mice
KW  - Microsomes, Liver
KW  - metabolism
KW  - Parasitic Sensitivity Tests
KW  - Permeability
KW  - Plasmodium falciparum
KW  - drug effects
KW  - Propafenone
KW  - analogs & derivatives
KW  - Solubility
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural
UR  - https://doi.org/10.1021/jm2005546
ER  -