TY - GEN AU - Neri,Paola AU - Ren,Li AU - Gratton,Kathy AU - Stebner,Erin AU - Johnson,Jordan AU - Klimowicz,Alexander AU - Duggan,Peter AU - Tassone,Pierfrancesco AU - Mansoor,Adnan AU - Stewart,Douglas A AU - Lonial,Sagar AU - Boise,Lawrence H AU - Bahlis,Nizar J TI - Bortezomib-induced "BRCAness" sensitizes multiple myeloma cells to PARP inhibitors SN - 1528-0020 PY - 2012///0214 KW - Adult KW - Animals KW - Antineoplastic Agents KW - administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols KW - adverse effects KW - BRCA1 Protein KW - genetics KW - Boronic Acids KW - Bortezomib KW - Cell Line, Tumor KW - Cells, Cultured KW - DNA Repair KW - drug effects KW - Enzyme Inhibitors KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Mice KW - Mice, SCID KW - Multiple Myeloma KW - drug therapy KW - Poly(ADP-ribose) Polymerase Inhibitors KW - Proteasome Endopeptidase Complex KW - Proteasome Inhibitors KW - Pyrazines KW - RNA, Messenger KW - metabolism KW - Rad51 Recombinase KW - Survival Analysis KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1182/blood-2011-06-363911 ER -