TY  - GEN
AU  - Weinstein,David S
AU  - Gong,Hua
AU  - Doweyko,Arthur M
AU  - Cunningham,Mark
AU  - Habte,Sium
AU  - Wang,Jin Hong
AU  - Holloway,Deborah A
AU  - Burke,Christine
AU  - Gao,Ling
AU  - Guarino,Victor
AU  - Carman,Julie
AU  - Somerville,John E
AU  - Shuster,David
AU  - Salter-Cid,Luisa
AU  - Dodd,John H
AU  - Nadler,Steven G
AU  - Barrish,Joel C
TI  - Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791826)
SN  - 1520-4804
PY  - 2012///0103
KW  - Alkaline Phosphatase
KW  - biosynthesis
KW  - Animals
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - chemical synthesis
KW  - Arthritis, Experimental
KW  - drug therapy
KW  - Cell Line, Tumor
KW  - Drug Partial Agonism
KW  - Edema
KW  - Glutamate-Ammonia Ligase
KW  - Heterocyclic Compounds, 3-Ring
KW  - Humans
KW  - In Vitro Techniques
KW  - Interleukin-1beta
KW  - blood
KW  - Male
KW  - Models, Molecular
KW  - Rats
KW  - Rats, Inbred Lew
KW  - Rats, Sprague-Dawley
KW  - Receptors, Glucocorticoid
KW  - agonists
KW  - Response Elements
KW  - Stereoisomerism
KW  - Structure-Activity Relationship
KW  - Thiadiazoles
KW  - Transcription Factor AP-1
KW  - genetics
KW  - Transcriptional Activation
KW  - Tumor Necrosis Factor-alpha
KW  - Tyrosine Transaminase
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm200879j
ER  -