Targeted systemic radiotherapy with scVEGF/177Lu leads to sustained disruption of the tumor vasculature and intratumoral apoptosis. [electronic resource]
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine Oct 2011
- 1630-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1535-5667
10.2967/jnumed.111.091629 doi
Angiogenesis Inhibitors--therapeutic use Animals Antibodies, Monoclonal, Humanized--therapeutic use Apoptosis--radiation effects Bevacizumab Breast Neoplasms--blood supply Cell Line, Tumor Cell Survival--radiation effects Combined Modality Therapy Endothelial Cells--radiation effects Female Humans Indoles--therapeutic use Lutetium--pharmacokinetics Mice Mice, Inbred BALB C Mice, Inbred ICR Mice, SCID Neovascularization, Pathologic--radiotherapy Pyrroles--therapeutic use Radioisotopes--pharmacokinetics Radiopharmaceuticals--pharmacokinetics Receptors, Vascular Endothelial Growth Factor--antagonists & inhibitors Sunitinib Vascular Endothelial Growth Factor A--pharmacokinetics