Bharadwaj, Uddalak <br/><br/>
Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression.  [electronic resource] 

 -  Molecular cancer  Aug 2011 
 - 106 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-4598 
<br/><br/><label>Standard No.: </label>10.1186/1476-4598-10-106  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Apoptosis Regulatory Proteins--genetics<br/>Caspase 3--metabolism<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Chromones--pharmacology<br/>Coumarins--pharmacology<br/>Cyclin A--metabolism<br/>Drug Resistance, Neoplasm<br/>Enzyme Activation<br/>GPI-Linked Proteins--genetics<br/>Gene Expression<br/>Gene Knockdown Techniques<br/>Genes, Reporter<br/>Humans<br/>I-kappa B Kinase--antagonists & inhibitors<br/>Interleukin-6--genetics<br/>Luciferases, Renilla--biosynthesis<br/>Mesothelin<br/>Morpholines--pharmacology<br/>Myeloid Cell Leukemia Sequence 1 Protein<br/>NF-kappa B--antagonists & inhibitors<br/>Pancreatic Neoplasms<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Protein Transport<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Proto-Oncogene Proteins c-bcl-2--metabolism<br/>RNA Interference<br/>Recombinant Proteins--genetics<br/>S Phase--drug effects<br/>Tumor Necrosis Factor-alpha--pharmacology