Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking the inhibitor of κB kinase α/inhibitor of κB-α/nuclear factor-κB pathway. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Nov 2011
- 694-703 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
1521-0103
10.1124/jpet.111.179820 doi
Animals Apoptosis--drug effects Bile Ducts--pathology Carbon Tetrachloride--toxicity Curcumin--pharmacology Electrophoretic Mobility Shift Assay Enzyme Inhibitors--pharmacology Hepatic Stellate Cells--drug effects I-kappa B Kinase--metabolism I-kappa B Proteins--metabolism Indoles--pharmacology Liver--drug effects Liver Cirrhosis--drug therapy Male NF-KappaB Inhibitor alpha NF-kappa B--metabolism Phosphorylation Protein Array Analysis Rats Rats, Wistar Signal Transduction--drug effects Solvents Swine--blood Transfection