Doshi, Utkarsh

Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. [electronic resource] - Journal of biomolecular screening Sep 2011 - 903-9 p. digital

Publication Type: Journal Article

1552-454X

10.1177/1087057111414900 doi


Automation, Laboratory
Biological Products--analysis
Cell Survival--drug effects
Cells, Cultured
Cryopreservation
Cytochrome P-450 CYP3A--metabolism
Cytochrome P-450 CYP3A Inhibitors
Drug Evaluation, Preclinical--methods
Drug Interactions
Enzyme Induction
Enzyme Inhibitors--pharmacology
Firefly Luciferin--analogs & derivatives
Hepatocytes--cytology
High-Throughput Screening Assays
Humans
Inhibitory Concentration 50
Kinetics
Reproducibility of Results
Sensitivity and Specificity