Modulation of AT-1R/MAPK cascade by an olmesartan treatment attenuates diabetic nephropathy in streptozotocin-induced diabetic mice. [electronic resource]
- Molecular and cellular endocrinology Jan 2012
- 104-11 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1872-8057
10.1016/j.mce.2011.07.041 doi
Angiotensin II Type 1 Receptor Blockers--pharmacology Angiotensin-Converting Enzyme 2 Animals Apoptosis--drug effects Diabetes Mellitus, Experimental Diabetic Nephropathies--prevention & control Enzyme Activation Gene Expression Imidazoles--pharmacology Intracellular Signaling Peptides and Proteins--metabolism Kidney--drug effects MAP Kinase Signaling System--drug effects Male Mice Mice, Inbred C57BL Oxidative Stress Peptidyl-Dipeptidase A--genetics Phosphorylation Protein Serine-Threonine Kinases--metabolism Proto-Oncogene Mas Proto-Oncogene Proteins--genetics Receptor, Angiotensin, Type 1--metabolism Receptors, G-Protein-Coupled--genetics Tetrazoles--pharmacology p38 Mitogen-Activated Protein Kinases--metabolism